Table II.
Pearson's correlation analysis between individual components of microRNA biogenesis.
| A, TCGA KIRC cohort | ||
|---|---|---|
| Correlations between components | Pearson's correlation coefficient value | P-value |
| DICER1 and DROSHA | 0.311 | 0.008 |
| DICER1 and AGO1 | 0.265 | 0.024 |
| DICER1 and TNRC6B | 0.609 | <0.001 |
| DICER1 and TNRC6C | 0.452 | <0.001 |
| DICER1 and AGO3 | 0.543 | <0.001 |
| DROSHA and DGCR8 | 0.364 | 0.002 |
| DROSHA and AGO1 | 0.258 | 0.029 |
| DROSHA and TNRC6B | 0.599 | <0.001 |
| DROSHA and TNRC6C | 0.316 | 0.007 |
| DROSHA and AGO3 | 0.267 | 0.023 |
| DGCR8 and TNRC6B | 0.350 | 0.003 |
| DGCR8 and TNRC6C | 0.336 | 0.004 |
| AGO1 and TNRC6B | 0.270 | 0.022 |
| AGO1 and AGO3 | 0.529 | <0.001 |
| TNRC6B and TNRC6C | 0.558 | <0.001 |
| TNRC6B and AGO3 | 0.365 | 0.002 |
| DICER1 and DGCR8 | 0.168 | 0.157 |
| DGCR8 and AGO1 | 0.095 | 0.428 |
| DGCR8 and AGO3 | 0.065 | 0.587 |
| AGO1 and TNRC6C | 0.162 | 0.175 |
| TNRC6C and AGO3 | 0.025 | 0.836 |
| B, Korean ccRCC cohort | ||
| Correlations between components | Pearson's correlation coefficient value | P-value |
| DICER1 and DROSHA | 0.877 | <0.001 |
| DICER1 and DGCR8 | 0.954 | <0.001 |
| DICER1 and AGO2 | 0.774 | <0.001 |
| DROSHA and DGCR8 | 0.840 | <0.001 |
| DROSHA and AGO2 | 0.641 | <0.001 |
| DGCR8 and AGO2 | 0.837 | <0.001 |
TCGA KIRC, The Cancer Genome Atlas kidney clear cell carcinoma; ccRCC, clear cell renal cell carcinoma; DGCR8, DiGeroge syndrome critical region gene 8; TNR, trinucleotide repeat containing.