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Fibrous pattern of pancreatic cancer. (A) Immature fibrosis contains an amorphous stromal substance composed of an amphophilic material intermingled with randomly oriented collagen fibers. (B) Mature fibrosis contains fine collagen fibers stratified into multilayers with eosinophilic hyalinization, and few fibroblasts. Arrows indicate fibroblasts. Hematoxylin and eosin stain. Original magnification, ×400.
