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. 2019 Aug 2;18(4):3537–3544. doi: 10.3892/ol.2019.10705

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Copyright: © Yu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — SAHA increases the expression of acH4, acH4K5 and acH4K12 in HepG2 cells. (A and B) Representative western blot images (one of three experiments) showing (A) the expression of acH4, acH4K5 acH4K12 and total histone H4 in HepG2 cells treated with SAHA at the indicated concentrations (0, 1, 6 and 12 µM) for 48 h and (B) their relative protein expression levels normalized to total histone H4. Relative protein expression indicates the ratio of the target protein (acH4, acH4K5 and acH4K12) level to the protein level of total histone H4. N=3. *P<0.05. SAHA, suberoylanilide hydroxamic acid; acH4, total acetylated histone H4; acH4K5, acetylated histone H4-lysine 5; acH4K12, acetylated histone H4-lysine 12.