Table VI.
Univariate and multivariate analysis for the 80 patients with esophageal squamous cell carcinoma with RNF2+P-AKT positive expression.
| Univariate analysis | Multivariate analysis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall survival | Progression-free survival | Overall survival | Progression-free survival | |||||||||
| Variables | HR | 95.0% CI | P-value | HR | 95.0% CI | P-value | HR | 95.0% CI | P-value | HR | 95.0% CI | P-value |
| Age (≤66/>66 years) | 1.704 | 1.030–2.819 | 0.036 | 1.477 | 0.908–2.402 | 0.116 | 1.957 | 1.175–3.259 | 0.010 | 1.620 | 0.990–2.650 | 0.055 |
| Tumor volume (≤25/>25 cm3) | 1.586 | 1.298–2.802 | 0.039 | 1.863 | 1.058–3.279 | 0.031 | 0.856 | 0.423–1.735 | 0.667 | 1.204 | 0.587–2.469 | 0.613 |
| T stage (1+2/3+4) | 1.871 | 1.081–3.239 | 0.023 | 1.932 | 1.133–3.296 | 0.016 | 2.125 | 1.222–3.698 | 0.008 | 2.047 | 1.196–3.504 | 0.009 |
| RNF2− -RNF2+++ | 2.752 | 1.319–5.740 | 0.007 | 0.888 | 0.706–1.119 | 0.315 | 0.833 | 0.622–1.115 | 0.219 | 0.992 | 0.616–1.597 | 0.974 |
| P-AKT− -P-AKT +++ | 0.045 | 0.005–0.420 | 0.003 | 1.025 | 0.755–1.392 | 0.872 | 0.739 | 0.513–1.065 | 0.105 | 1.533 | 0.622–3.781 | 0.353 |
| RNF2 and P-AKT | 1.713 | 1.017–2.886 | 0.040 | 1.596 | 0.966–2.636 | 0.068 | 2.010 | 1.183–3.415 | 0.010 | 3.341 | 1.758–6.351 | <0.001 |
| Expression (other/both positive) | ||||||||||||
RNF2, Ring finger protein 2; P-AKT, phosphor-protein kinase B; Other, including patients with RNF2-negative/P-AKT-negative, RNF2-positive/P-AKT-negative, RNF2-negative/P-AKT-positive; HR, hazard ration; CI, confidence interval.