Table 4.
Relationship Between Demographic, Clinical, and Laboratory Characteristics and 25(OH)D Level Categories
| Parameter | Category of 25(OH)D | P | ||
|---|---|---|---|---|
| Sufficiency | Insufficiency | Deficiency | ||
| Age of asthma onset (year) (mean ± SD) | 6.6 ± 2.7 | 4.9 ± 3.4 | 6.6 ± 3.8 | 0.09 |
| Asthma severity, n (%) | ||||
| Mild | 15 (75) | 17 (48.6) | 28 (62.2) | 0.3 |
| Moderate | 3 (15) | 13 (37.1) | 10 (22.2) | |
| Severe | 2 (10) | 5 (14.3) | 7 (15.6) | |
| Asthma control, n (%) | ||||
| Controlled | 17 (85) | 21 (60) | 27 (60) | 0.3 |
| Partially controlled | 1 (5) | 7 (20) | 10 (22.2) | |
| Uncontrolled | 2 (10) | 7 (20) | 8 (17.8) | |
| Treatment step, n (%) | ||||
| Treatment step 2 | 11 (55) | 15 (42.9) | 20 (44.5) | 0.7 |
| Treatment step 3 | 7 (35) | 11 (31.4) | 15 (33.3) | |
| Treatment step 4 | 2 (10) | 9 (25.7) | 10 (22.2) | |
| Number of asthma attacks (mean ± SD) | 7.8 ± 7.9 | 12.2 ± 8.7 | 11.2 ± 10.7 | 0.8 |
| FEV1 (mean ± SD) (%) | 94.5 ± 19.8 | 81.3 ± 21.7 | 83.7 ± 16.2 | 0.04 |
| PEF (mean ± SD) (%) | 87.0 ± 25.9 | 79.8 ± 24.2 | 71.8 ± 16.1 | 0.02 |
| Positive skin prick test, n (%) | 5 (12.8) | 15 (38.5) | 19 (48.7) | 0.3 |
| Total IgE level (mean ± SD) | 446.2 ± 563.6 | 286.4 ± 370.5 | 341.1 ± 560.9 | 0.5 |
| Peripheral eosinophilia (mean ± SD) | 354.5 ± 157.5 | 364.6 ± 299.2 | 265.8 ± 214.5 | 0.1 |
| FeNO (ppb) (mean ± SD) | 20.0 ± 8.9 | 27.7 ± 17.3 | 27.8 ± 22 | 0.2 |
| FeNO n (%) | ||||
| ≤20 ppb | 12 (60) | 16 (45.7) | 26 (57.8) | 0.6 |
| 21–34 ppb | 5 (25) | 9 (25.7) | 8 (17.8) | |
| ≥35 ppb | 3 (15) | 10 (28.6) | 11 (24.4) | |
The ANOVA and chi-square tests for comparison of more than 2 groups have been used.
ANOVA, analysis of variance; FeNO, fractional nitric oxide in exhaled breath; FEV1, forced expiratory volume in 1 s; PEF, peak expiratory flow.