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PI3K/Akt signaling pathway activated by HMGB1 regulated F-actin level in EPCs. EPCs were untreated (A) or were treated with 100 ng/ml HMGB1 alone (B). Plus 20 μM LY294002 (C), or plus 20 μg/ml anti-RAGE-antibody (D) to 12 h. The EPCs were treated by HMGB1, which led to increased fluorescent intensity of F-actin (E), but this process was blocked by LY294002 and anti-RAGE-antibody. (scale bar=20 μm) (* P<0.05).
