Table 2. Hub genes in the protein-protein network screened by topological features.

Gene	Degree		Betweenness		Closeness		Eigenvector
FYN	12	FYN	983.10	FYN	0.096	FYN	0.42
PIK3R1	10	PIK3R1	716.77	PIK3R1	0.096	PIK3R1	0.39
ESR1	8	ESR1	658.76	KLF5	0.095	NTF3	0.33
NTF3	7	GATA6	543.73	ESR1	0.095	EPHA2	0.32
EPHA2	7	KLF5	529.64	EPHA2	0.093	NRG1	0.30
WNT5A	7	SOX5	438	NRG1	0.093	EPHA4	0.24
NRG1	6	WNT5A	405.05	FOXO1	0.092	FGF1	0.24
FOXO1	6	PLXNA2	352	NTF3	0.092	MBP	0.22
EPHA4	5	CELF2	274	ITGA2	0.092	MAP2	0.18
MBP	5	GDF5	270	GATA6	0.091	ESR1	0.15