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. 2019 Sep 6;7:e7544. doi: 10.7717/peerj.7544

Table 4. GO biological process term enrichment for the genes in the PPI network.

Term p-Value Genes
GO:0042981—regulation of apoptotic process 6.04E-05 RASSF5, TNFRSF11B, DUSP1, NTF3, FYN, GDF5, ESR1
GO:0032148—activation of protein kinase B activity 7.76E-05 WNT5A, NTF3, FGF1, NRG1
GO:0007596—blood coagulation 3.06E-04 PRKAR2B, FYN, GATA6, ITGA2, PDGFD, PLAU
GO:0071560—cellular response to transforming growth factor beta stimulus 5.22E-04 WNT5A, FYN, SOX5, PDGFD
GO:0043066—negative regulation of apoptotic process 6.03E-04 WNT5A, EDNRB, DUSP1, RPS6KA1, ID1, GATA6, FOXO1, PIK3R1
GO:0045944—positive regulation of transcription from RNA polymerase II promoter 1.01E-03 KLF5, WNT5A, RPS6KA1, GATA6, HIPK2, TFEB, ESR1, FOXO1, FGF1, NRG1, PIK3R1
GO:0045893—positive regulation of transcription, DNA-templated 1.25E-03 KLF5, WNT5A, GATA6, HIPK2, TFEB, ESR1, FOXO1, LGR4
GO:0018108—peptidyl-tyrosine phosphorylation 1.47E-03 EPHA4, FYN, FGF1, NRG1, EPHA2
GO:0014066—regulation of phosphatidylinositol 3-kinase signaling 2.02E-03 FYN, FGF1, NRG1, PIK3R1
GO:0030335—positive regulation of cell migration 2.88E-03 NTF3, PDGFD, FGF1, PIK3R1, PLAU
GO:0046854—phosphatidylinositol phosphorylation 3.43E-03 FYN, FGF1, NRG1, PIK3R1
GO:0030182—neuron differentiation 3.53E-03 WNT5A, ID1, HIPK2, EPHA2
GO:0008284—positive regulation of cell proliferation 3.70E-03 KLF5, EDNRB, NTF3, HIPK2, PDGFD, FGF1, NRG1
GO:0048015—phosphatidylinositol-mediated signaling 4.80E-03 FYN, FGF1, NRG1, PIK3R1
GO:0000187—activation of MAPK activity 4.93E-03 WNT5A, NTF3, FGF1, NRG1
GO:0045892—negative regulation of transcription, DNA-templated 5.16E-03 WNT5A, ID1, GATA6, FOXO1, NRG1, ZBTB18, LGR4
GO:0045766—positive regulation of angiogenesis 6.02E-03 WNT5A, GATA6, HIPK2, FGF1
GO:0000122—negative regulation of transcription from RNA polymerase II promoter 7.94E-03 KLF5, EDNRB, ID1, GATA6, HIPK2, ESR1, FOXO1, ZBTB18
GO:0043524—negative regulation of neuron apoptotic process 8.79E-03 NTF3, FYN, GDF5, HIPK2
GO:0035556—intracellular signal transduction 9.37E-03 PRKAR2B, RASSF5, DUSP1, RPS6KA1, FYN, NRG1
GO:0045213—neurotransmitter receptor metabolic process 9.62E-03 DMD, NRG1
GO:0060750—epithelial cell proliferation involved in mammary gland duct elongation 1.28E-02 WNT5A, ESR1
GO:0048146—positive regulation of fibroblast proliferation 1.31E-02 WNT5A, ESR1, PDGFD
GO:0043406—positive regulation of MAP kinase activity 1.54E-02 PDE5A, PDGFD, FGF1
GO:0043627—response to estrogen 1.86E-02 TNFRSF11B, GATA6, ESR1
GO:0014068—positive regulation of phosphatidylinositol 3-kinase signaling 1.86E-02 FYN, PDGFD, NRG1
GO:0048841—regulation of axon extension involved in axon guidance 2.23E-02 PLXNA4, PLXNA2
GO:0008366—axon ensheathment 2.23E-02 NRG1, MBP
GO:0050966—detection of mechanical stimulus involved in sensory perception of pain 2.54E-02 FYN, ITGA2
GO:0008286—insulin receptor signaling pathway 2.61E-02 PDK4, FOXO1, PIK3R1
GO:0090630—activation of GTPase activity 2.67E-02 WNT5A, NTF3, EPHA2
GO:0060068—vagina development 2.89E-02 WNT5A, ESR1
GO:0021785—branchiomotor neuron axon guidance 2.86E-02 PLXNA4, PLXNA2
GO:0007165—signal transduction 3.11E-02 TNFRSF11B, NTF3, RPS6KA1, PDE5A, NR3C2, ESR1, FGF1, PIK3R1, PLAU
GO:0048013—ephrin receptor signaling pathway 3.12E-02 EPHA4, FYN, EPHA2
GO:0031643—positive regulation of myelination 3.17E-02 WASF3, NRG1
GO:0010976—positive regulation of neuron projection development 3.33E-02 WNT5A, FYN, DMD
GO:1901653—cellular response to peptide 3.48E-02 KLF5, ID1
GO:0046849—bone remodeling 3.48E-02 LGR4, EPHA2
GO:0033628—regulation of cell adhesion mediated by integrin 3.48E-02 EPHA2, PLAU
GO:0001525—angiogenesis 3.49E-02 KLF5, PTPRB, ID1, FGF1
GO:0007179—transforming growth factor beta receptor signaling pathway 3.53E-02 ID1, GDF5, HIPK2
GO:0008584—male gonad development 3.68E-02 WNT5A, GATA6, ESR1
GO:1902287—semaphorin-plexin signaling pathway involved in axon guidance 3.79E-02 PLXNA4, PLXNA2
GO:0055119—relaxation of cardiac muscle 3.79E-02 RGS2, PDE5A
GO:0007169—transmembrane receptor protein tyrosine kinase signaling pathway 3.82E-02 NTF3, FYN, NRG1
GO:0001678—cellular glucose homeostasis 4.41E-02 FOXO1, PIK3R1
GO:0060065—uterus development 4.41E-02 WNT5A, ESR1
GO:0006636—unsaturated fatty acid biosynthetic process 4.72E-02 ELOVL2, SCD5