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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Cancer Res. 2019 Jul 12;79(17):4339–4347. doi: 10.1158/0008-5472.CAN-19-0214

Figure 1. Three novel molecular subtypes of lung carcinoids with mutational, gene expression and DNA CpG methylation with distinct clinical features.

Figure 1.

a) Mutated genes in lung carcinoids on a 354-cancer gene panel. Samples summary from DNA (n=29), methylation (n=18), RNAseq (n=30), carcinoids samples (atypical (n=13, grey) and typical (n=17, white)) and specimen location (endobronchial in white (n=9) and peripheral in grey (n=21)). Samples are grouped according to their gene expression and DNA methylation pattern. Orange = subtype 1 (LC1), Red = subtype 2 (LC2), Blue = subtype 3 (LC3). Column represents sample and row represents gene name. Gene expression (n=30) and DNA CpG methylation (n=18) analysis revealed three lung carcinoid subtypes using unsupervised clustering and PCA analysis: b) Heatmap of unsupervised clustering of top 100 variably expressed gene across all samples. c) PCA of top 3000 variably expressed genes. d) Heatmap of unsupervised clustering of top 500 variable methylated CpG probes. e) PCA on top 3000 variable methylated CpG probes.