Table 2.

Pharmacokinetic parameters of paracetamol, oral administration 500 mg per animal (mean ± SD, n = 4). No statistical difference was observed between the study legs.

Pharmacokinetic parameters
	$\mathrm{F}\mathrm{a}\mathrm{s}\mathrm{t}\mathrm{e}\mathrm{d}$	${\mathrm{F}\mathrm{E}\mathrm{D}}_{\mathrm{F}\mathrm{D}\mathrm{A}\mathrm{b}\mathrm{r}\mathrm{e}\mathrm{a}\mathrm{k}\mathrm{f}\mathrm{a}\mathrm{s}\mathrm{t}}$	${\mathrm{F}\mathrm{E}\mathrm{D}}_{\mathrm{P}\mathrm{i}\mathrm{g}\mathrm{p}\mathrm{e}\mathrm{l}\mathrm{l}\mathrm{e}\mathrm{t}}$
cmax (μg/mL)	16.41 ± 5.48	11.88 ± 4.64	14.76 ± 2.46
tmax (h)a	3.25 (2.5–5.0)	3.75 (3.0–5.0)	3.75 (2.5–6.0)
AUC0→8h (μg⋅h/mL)	70.02 ± 20.70	61.32 ± 13.07	74.71 ± 11.04
AUC0→24h (μg⋅h/mL)	81.40 ± 24.41	70.47 ± 14.97	95.64 ± 17.16
MAT (h)b	3.89 ± 0.77	4.16 ± 0.63	4.77 ± 0.96
MRT p.o. (h)	5.70 ± 0.74	5.97 ± 0.20	6.58 ± 0.90

^aMedian (range).

^bMAT was calculated with i.v. data previously published from (Henze et al., 2018a).