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. 2019 Aug 30;6(1):e000454. doi: 10.1136/bmjresp-2019-000454

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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The comparative oxygen content of circulating blood within the setting of physiologically relevant anaemia and reduced Hb oxygen saturation. In a patient with an Hb of 11 g/dL and oxygen saturations of 88%, increasing the Hb by 1 g/dL has double the impact on oxygen content than improving Hb oxygen saturation by 4%. Improvements in oxygen content may occur with increased Hb even in the setting of normal saturations (eg, as may be relevant in concomitant cardiac failure given that oxygen delivery is the product of cardiac output and oxygen content).