Table 1.

Comparison of the commercially-available thrombopoietin receptor agonists.^20,42,43

	Romiplostim	Eltrombopag	Avatrombopag	Lusutrombopag
Molecular structure	Peptide	Small molecule	Small molecule	Small molecule
TPO receptor site of action	Extracellular domain	Transmembrane domain	Transmembrane domain	Transmembrane domain
Route of administration	Subcutaneous	Oral	Oral	Oral
Dosing frequencya	Weekly	Daily	Daily	Daily
Relevant food interactions	N/A	Yes	No	No
Current indications	Immune thrombocytopenia (adults and children)	Immune thrombocytopenia (adults and children) Hepatitis C-associated thrombocytopenia Severe aplastic anemia	Periprocedural thrombocytopenia in CLD patients Immune thrombocytopenia (adults)	Periprocedural thrombocytopenia in CLD patients

Note: ^aPer drug label. Modified with permission from Al-Samkari, H. Avatrombopag maleate for the treatment of periprocedural thrombocytopenia in patients with chronic liver disease. Drugs Today (Barc) 2018, 54(11): 647-655. © 2018 Clarivate Analytics.⁴⁴

Abbreviations: TPO, thrombopoietin; CLD, chronic liver disease; N/A, not applicable.