Table 5.
Relationship of prominent SNPs with the COPD risk stratified by gender
| SNP | Model | Genotype | Males | Females | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Control | Case | OR (95% CI) | P-value | Control | Case | OR (95% CI) | P-value | |||
| rs4803420 | Co-dominant | G/G | 194 (57.7%) | 168 (70.6%) | 1.00 | 97 (57.1%) | 58 (77.3%) | 1.00 | ||
| G/T | 129 (38.4%) | 61 (25.6%) | 0.45 (0.27–0.73) | 0.001* | 64 (37.7%) | 14 (18.7%) | 0.36 (0.18–0.74) | 0.006* | ||
| T/T | 13 (3.9%) | 9 (3.8%) | 0.95 (0.32–2.85) | 0.928 | 9 (5.3%) | 3 (4.0%) | 0.74 (0.18–3.06) | 0.681 | ||
| Dominant | G/G | 194 (57.7%) | 168 (70.6%) | 1.00 | 97 (57.1%) | 58 (77.3%) | 1.00 | |||
| G/T-T/T | 142 (42.3%) | 70 (29.4%) | 0.49 (0.3–0.78) | 0.003* | 73 (42.9%) | 17 (22.7%) | 0.40 (0.21–0.79) | 0.008* | ||
| Recessive | G/G -G/T | 323 (96.1%) | 229 (96.2%) | 1.00 | 161 (94.7%) | 72 (96.0%) | 1.00 | |||
| T/T | 13 (3.9%) | 9 (3.8%) | 1.24 (0.42–3.68) | 0.693 | 9 (5.3%) | 3 (4.0%) | 1.01 (0.25–4.10) | 0.994 | ||
| Log-additive | – | – | – | 0.61 (0.41–0.91) | 0.017* | – | – | 0.52 (0.29–0.93) | 0.026* | |
| Allele | T | 517 (76.9%) | 397 (83.4%) | 1.00 | 258 (75.9%) | 130 (96.7%) | 1.00 | |||
| G | 155 (23.1%) | 79 (16.6%) | 0.66 (0.49–0.90) | 0.007* | 82 (24.1%) | 20 (13.3%) | 0.48 (0.28–0.82) | 0.008* | ||
| rs1038376 | Co-dominant | A/A | 251 (74.5%) | 150 (63.0%) | 1.00 | 135 (79.0%) | 36 (48.0%) | 1.00 | ||
| A/T | 83 (24.6%) | 78 (32.8%) | 1.79 (1.09–2.94) | 0.022* | 35 (20.5%) | 38 (50.7%) | 4.32 (2.25–8.32) | 1.19E-05* | ||
| T/T | 3 (0.9%) | 10 (4.2%) | 5.30 (0.82–34.32) | 0.080 | 1 (0.6%) | 1 (1.3%) | 2.30 (0.11–47.29) | 0.588 | ||
| Dominant | A/A | 251 (74.5%) | 150 (63.0%) | 1.00 | 135 (79.0%) | 36 (48.0%) | 1.00 | |||
| A/T-T/T | 86 (25.5%) | 88 (37.0%) | 1.91 (1.18–3.10) | 0.009* | 36 (21.0%) | 39 (52.0%) | 4.24 (2.22–8.11) | 1.25E-05* | ||
| Recessive | A/A-A/T | 334 (99.1%) | 228 (95.8%) | 1.00 | 170 (99.4%) | 74 (98.7%) | 1.00 | |||
| T/T | 3 (0.9%) | 10 (4.2%) | 4.50 (0.70–28.81) | 0.113 | 1 (0.6%) | 1 (1.3%) | 1.41 (0.07–28.72) | 0.823 | ||
| Log-additive | – | – | – | 1.89 (1.21–2.94) | 0.005* | – | – | 3.82 (2.04–7.15) | 2.89E-05* | |
| Allele | A | 585 (86.8%) | 378 (79.4%) | 1.00 | 305 (89.2%) | 110 (73.3%) | 1.00 | |||
| T | 89 (13.2%) | 98 (20.6%) | 1.70 (1.24–2.34) | 0.001* | 37 (10.8%) | 40 (26.7%) | 3.00 (1.82–4.93) | 8.43E-06* | ||
| rs12979270 | Co-dominant | A/A | 163 (49.1%) | 113 (48.1%) | 1.00 | 86 (52.4%) | 29 (39.7%) | 1.00 | ||
| A/C | 148 (44.6%) | 104 (44.2%) | 0.99 (0.62–1.57) | 0.952 | 68 (41.5%) | 35 (480%) | 1.41 (0.75–2.67) | 0.284 | ||
| C/C | 21 (6.3%) | 18 (7.7%) | 0.95 (0.34–2.61) | 0.918 | 10 (6.1%) | 9 (12.3%) | 2.77 (0.91–8.46) | 0.074 | ||
| Dominant | A/A | 163 (49.1%) | 113 (48.1%) | 1.00 | 86 (52.4%) | 29 (39.7%) | 1.00 | |||
| A/C-C/C | 169 (50.9%) | 122 (51.9%) | 0.98 (0.63–1.54) | 0.936 | 78 (47.6%) | 44 (60.3%) | 1.57 (0.85–2.88) | 0.147 | ||
| Recessive | A/A-A/C | 311 (93.7%) | 217 (92.3%) | 1.00 | 154 (93.9%) | 64 (87.7%) | 1.00 | |||
| C/C | 21 (6.3%) | 18 (7.7%) | 0.95 (0.35–2.57) | 0.927 | 10 (6.1%) | 9 (12.3%) | 2.33 (0.8–6.79) | 0.121 | ||
| Log-additive | – | – | – | 0.98 (0.67–1.43) | 0.918 | – | – | 1.56 (0.97–2.51) | 0.069 | |
| Allele | A | 474 (71.4%) | 330 (70.2%) | 1.00 | 240 (73.2%) | 93 (63.7%) | 1.00 | |||
| C | 190 (28.6%) | 140 (29.8%) | 1.06 (0.82–1.37) | 0.691 | 88 (26.8%) | 53 (36.3%) | 1.55 (1.03–2.36) | 0.039* | ||
Notes: P-values were calculated by unconditional logistic regression analysis with adjustments for age; *P<0.05 and P values shown in bold are statistically significant.
Abbreviations: SNP, single-nucleotide polymorphism; Alleles A/B, minor/major alleles; MAF, minor allele frequency; OR, odds ratio; 95% CI, 95% confidence interval.