Table 7.

Haplotype frequencies of CYP2B6 gene polymorphisms and the association with COPD risk

	SNP	Haplotype	Freq (Case)	Freq (Control)	Without adjusted		With adjusted
OR (95% CI)	P-value	OR (95% CI)	P-value
Total	rs4803420|rs1038376|rs12979270	GAC	0.313	0.278	1.20 (0.96–1.51)	0.114	1.17 (0.87–1.58)	0.290
		GTA	0.779	0.873	0.49 (0.37–0.64)	4.93E-07*	0.45 (0.31–0.65)	1.69E-05*
		TAA	0.839	0.764	1.63 (1.25–2.12)	2.97E-04*	1.69 (1.22–2.34)	0.002*
		GAA	0.695	0.642	1.28 (1.03–1.60)	0.026*	1.24 (0.94–1.63)	0.133
Males	rs4803420|rs1038376|rs12979270	GAC	0.298	0.284	1.08 (0.82–1.41)	0.597	1.00 (0.69–1.47)	0.992
		GTA	0.794	0.866	0.59 (0.42–0.81)	0.001*	0.56 (0.35–0.87)	0.011*
		TAA	0.832	0.769	1.50 (1.11–2.04)	0.009*	1.60 (1.06–2.39)	0.024*
		GAA	0.672	0.651	1.10 (0.86–1.42)	0.454	1.00 (0.72–1.39)	0.997
Females	rs4803420|rs1038376|rs12979270	GAC	0.363	0.265	1.62 (1.05–2.49)	0.029*	1.58 (0.98–2.54)	0.060
		GTA	0.733	0.889	0.28 (0.16–0.49)	1.01E-05*	0.27 (0.15–0.52)	5.69E-05*
		TAA	0.863	0.753	2.05 (1.20–3.51)	0.009*	1.99 (1.12–3.54)	0.020*
		GAA	0.767	0.624	2.18 (1.35–3.52)	0.001*	2.15 (1.28–3.62)	0.004*

Notes: Block comprised the three closely linked SNPs rs4803420, rs1038376, and rs12979270; P-values were calculated with Pearson’s χ² tests; *P<0.05 and P values shown in bold are statistically significant.

Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval.