Figure 1.
Time to all-cause discontinuation of antipsychotics across studies. Time to all-cause discontinuation is consistently longer with olanzapine compared with other first- and second-generation antipsychotics. CATIE: From New England Journal of Medicine. Lieberman et al. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. Volume 353, page 1219. Copyright ©2005 Massachusetts Medical Society. Reprinted with permission from Massachusetts Medical Society.56 EUFEST: Reprinted from The Lancet, Volume 371, Kahn et al. Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial, Pages 1085-1097, Copyright 2008, with permission from Elsevier.40 Kinon et al, 2006: Kinon et al, Differential rates of treatment discontinuation in clinical trials as a measure of treatment effectiveness for olanzapine and comparator atypical antipsychotics for schizophrenia. Journal of Clinical Psychopharmacology. 2006;26(6):632–637.35 SOHO: Reprinted from European Neuropsychopharmacology. Volume 17. Haro et al. Three-year antipsychotic effectiveness in the outpatient care of schizophrenia: observational versus randomized studies results. Pages 235–244. Copyright 2007, with permission from Elsevier.59