Table 2.

Distribution of 89 BRCA1/2-associated MBC cases and 157 unaffected male BRCA1/2 mutation carriers according to genotype frequencies of CYP1A1 rs743572, CYP1B1 rs1056836 and rs1800440 and MBC risk estimates.

Polymorphism	Genotype	BRCA1/2 MBC cases (n = 89)		Unaffected male BRCA1/2 mutation carriers (n = 157)		OR (95% CI)	P value
		n	%	n	%
CYP17A1 c.-34T>C	TT	31	34.8	57	36.3	Ref
rs743572	TC	48	53.9	71	45.2	1.08 (0.53–2.20)	0.83
	CC	10	11.3	29	18.5	0.81 (0.29–2.23)	0.68
	Co-dominant					0.94 (0.59–1.50)	0.79
CYP1B1 p.Leu432Val	GG	34	38.2	67	42.7	Ref
rs1056836	GC	44	49.4	70	44.6	1.42 (0.71–2.86)	0.32
	CC	11	12.4	20	12.7	0.62 (0.20–1.92)	0.41
	Co-dominant					0.95 (0.59–1.54)	0.83
CYP1B1 p.Asn453Ser	AA	53	59.5	96	61.2	Ref
rs1800440	AG	32	36.0	55	35.0	1.44 (0.72–2.91)	0.31
	GG	4	4.5	6	3.8	2.97 (0.71–12.38)	0.13
	Co-dominant					1.57 (0.91–2.73)	0.11