Table 3.

Multivariate cox proportional hazards regression analysis for gallbladder neuroendocrine neoplasm patients.

Variables		Cancer-specific survival		Overall survival
		HR (95% CI)	P	HR (95% CI)	P
Age at diagnosis, years	≤65	1.00	–	1.00	–
	>65	1.65 (1.14–2.40)	0.008	1.78 (1.26–2.52)	0.001
Marital status	Married	1.00	–	1.00	–
	Unmarrieda	1.89 (1.27–2.81)	0.002	1.91 (1.33–2.73)	<0.001
Tumor size (cm)	≤2	1.00	–	1.00	–
	2–5	1.83 (0.84–4.01)	0.129	1.50 (0.79–2.84)	0.215
	>5	2.95 (1.37–6.39)	0.006	2.15 (1.13–4.09)	0.020
	Unknown	4.84 (2.29–10.21)	<0.001	3.32 (1.82–6.06)	<0.001
SEER stage	Localized	1.00	–	1.00	–
	Regional	4.50 (1.62–12.49)	0.004	6.06 (3.05–12.06)	<0.001
	Distant	9.42 (3.32–26.73)	<0.001	10.60 (5.15–21.82)	<0.001
N stage	N0	1.00	–	NA
	N1	1.03 (0.68–1.57)	0.881
	Unknown	2.16 (1.19–3.91)	0.011
Histological categoryb	GB-NEC	1.00	–	NA
	GB-NET	0.22 (0.06–0.86)	0.030
Surgery at primary site	No	NA		1.00	–
	Yes			0.58 (0.37–0.90)	0.014

^aUnmarried included single, divorced, widowed, and separated; ^bGB-NEC included neuroendocrine carcinoma, large-cell neuroendocrine carcinoma, small-cell carcinoma, and mixed adenoneuroendocrine carcinoma of the gallbladder and GB-NET included carcinoid tumors and atypical carcinoid tumors of the gallbladder. Bold indicates statistical significance.