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. 2019 Aug 5;8(9):1262–1272. doi: 10.1530/EC-19-0297

Table 2.

Cortisol nadir mean values and times, ACTH nadir mean values and times and ACTH before hospital discharge (last ACTH).

MRI identification of the adenoma SSa (P)
Microadenoma (n = 43) Macroadenoma (n = 16) No imaging data (n = 6)
Mean (s.d.) Mean (s.d.) Mean (s.d.)
Cortisol nadir (nmol/L) 81.1b (117.0) 254.1b (305.4) 186.2 (342.1) 0.016
Time to cortisol nadir (h) 46.6c (28.2) 84.3c (38.7) 56.0 (29.7) 0.001
ACTH nadir (pmol/L) 3.1b (3.6) 9.6b (13.4) 2.6 (2.0) 0.011
Time to ACTH nadir (h) 46.6b (33.0) 77.7b (38.9) 38.0 (23.1) 0.006
Last ACTH measurement (pmol/L) 3.1b (3.5) 9.6b (13.4) 2.6 (2.0) 0.010
Time of last ACTH measurement (h) 130 (52) 162 (54) 111 (37) 0.061

aSS, statistical significance (ANOVA); bSignificant differences between macroadenomas and microadenomas (Scheffe test and Bonferroni test; P < 0.05); cSignificant differences between macroadenomas and microadenomas (Scheffe test and Bonferroni test; P < 0.01).