. 2019 Aug 5;8(9):1262–1272. doi: 10.1530/EC-19-0297
This work is licensed under a Table 4.
Analysis of cortisol and ACTH nadir levels, last determination of ACTH and the respective time values, according to the impact of surgery upon the clinical course of Cushing’s disease.
| Variables | Persistence | Recurrence | Early remission | Remission at 3 months | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean (s.d.) | No | Yes | SSa | No | Yes | SSa | No | Yes | SSa | No | Yes | SSa |
| Cortisol nadir (nmol/L) | 76.1 (109.0) | 606.7 (286.4) | P < 0.001 | 59.6 (101.0) | 113.4 (119.2) | P = 0.080 | 165.5 (149.8) | 29.2 (11.6) | P < 0.001 | 190.1 (149.0) | 72.3 (106.8) | P = 0.134 |
| Time to cortisol nadir (h) | 54.4 (32.1) | 76.1 (50.4) | P = 0.117 | 46.35 (28.31) | 72.28 (33.44) | P = 0.04 | 81.70 (35.61) | 40.03 (17.83) | P < 0.001 | 115.00 (77.78) | 52.23 (28.59) | P = 0.005 |
| ACTH nadir (pmol/L) | 2.9 (2.4) | 18.6 (17.8) | P < 0.001 | 2.1 (1.6) | 4.8 (2.8) | P < 0.001 | 4.5 (2.5) | 2.1 (1.9) | P < 0.001 | 6.5 (4.4) | 2.8 (2.2) | P = 0.031 |
| Time to ACTH nadir (h) | 52.6 (35.5) | 61.0 (44.4) | P = 0.555 | 42.13 (27.19) | 75.33 (41.18) | P = 0.001 | 78.05 (44.36) | 38.86 (19.14) | P < 0.001 | 89.00 (100.41) | 51.29 (32.68) | P = 0.141 |
| Last ACTH measurement (pmol/L) | 2.9 (2.4) | 18.6 (17.8) | P < 0.001 | 2.1 (1.6) | 4.8 (2.8) | P < 0.001 | 4.5 (2.5) | 2.1 (1.9) | P < 0.001 | 6.5 (4.4) | 2.8 (2.2) | P = 0.029 |
| Time of last ACTH measurement (h) | 134 (52) | 164 (63) | P = 0.190 | 130.97 (57.50) | 139.56 (37.24) | P = 0.566 | 148.85 (45.39) | 125.49 (53.72) | P = 0.105 | 123.00 (66.47) | 134.07 (51.90) | P = 0.769 |
aSS, statistical significance (Student t-test). Bold indicates statistical significance.