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. 2019 May 24;1:100016. doi: 10.1016/j.ijpx.2019.100016

Fig. 4.

Fig. 4

Plasma concentration-time profiles in rat (mean profiles and standard deviation error bars for n = 3 to 5). Red diamond: Intramuscular (IM) in situ forming gel formulation 1 dosed at 6 mg eq./kg (10 mg/g bedaquiline fumarate salt in 23.5% (w/w) P338 in NMP/water 25/75% (v/v)); blue square: IM in situ forming gel formulation 2 dosed at 6 mg eq./kg (10 mg/g bedaquiline fumarate salt in 20.0% (w/w) P338/P407 20.4/79.6% (w/w) in NMP/water 25/75% (v/v)); orange circle: IM PEG400 solution formulation 5 dosed at 3 mg eq./kg (eq. 5 mg/mL bedaquiline fumarate salt in PEG400/water 50/50% (v/v)); black triangle: intravenous solution formulation 5 dosed at 5 mg eq./kg.