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. 2019 Sep 9;14(9):e0222361. doi: 10.1371/journal.pone.0222361

Table 2. Associations between alcohol, tobacco and cannabis use and job loss at one-year among 18,879 participants from the CONSTANCES cohort, adjusting for age, gender, self-reported health and depressive symptoms.

Type of model Each substance successively entered All substances simultaneously entered
OR 95%CI p value OR 95%CI p value
Alcohol usea
    Dangerous 1.46 1.23 1.73 <0.001 1.22 1.02 1.46 0.030
    Problematic or Dependence 1.92 1.34 2.75 <0.001 1.42 0.98 2.05 0.067
Tobacco useb
    Former smoker 1.26 1.09 1.46 0.002 1.08 0.93 1.26 0.320
    Light smoker 1.54 1.27 1.86 <0.001 1.17 0.96 1.44 0.128
    Moderate smoker 1.69 1.36 2.10 <0.001 1.29 1.02 1.63 0.034
    Heavy smoker 1.78 1.26 2.54 0.001 1.33 0.92 1.92 0.126
Cannabis usec
    Consumption more than 12 months ago 1.45 1.27 1.66 <0.001 1.35 1.17 1.56 <0.001
    Less than once a month 1.87 1.43 2.45 <0.001 1.62 1.22 2.15 0.001
    Once a month or more 2.68 2.10 3.42 <0.001 2.19 1.68 2.87 <0.001

OR: Odds ratios; 95%CI: Confidence interval at 95%

a Categories are defined from Alcohol Use Disorders Identification scores as follows: Mild (0–7), Dangerous (8–15), Problematic (16–19) and Dependence (20–40), with Mild category as reference

b Categories of current smokers are defined as follows: Light (1 to 9 cigarettes per day), Moderate (10 to 19) and Heavy (>19) consumers, with never smokers as reference category

c Reference category is never use. Adjustments variables were as follows: gender, age in three categories (<30; ≥30 and <50 and ≥50), self-reported health was used as a binary variable from an 8-points Likert scale, and depressive state defined as a total score ≥19 at the Center for Epidemiologic Studies Depression (CESD). Significant associations are presented in bold (i.e. p<0.05).