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. 2019 Sep 9;14(9):e0222352. doi: 10.1371/journal.pone.0222352

Fig 8. The effect of CCR2 knockout on ER stress and ROS.

Fig 8

(a) mRNA levels of xBP1 and Nox4 by semiquantitative real-time PCR, corrected by β-actin mRNA level in the same sample. (b) Western blots (left) and densitometry (right) demonstrating that HFD-induced increases of xBP1, Bip, Nox4, and TNF-α were decreased by CCR2 depletion in HFD KO. Data are presented as the means ± SEM, n = 4 per group. RD WT, Regular diet wild type; RD KO, Regular diet CCR2 knockout; HFD WT, High-fat diet wild type; HFD KO, High-fat diet CCR2 knockout. *P < 0.05 compared to that in RD WT; #P < 0.05 compared to that in HFD WT.