Figure 1.
Protocol design outline with an example subject. (a) Study timeline. (b) Representative example of 1 day in the room calorimeter showing EE (black) and motion (blue), including two resting measurement periods (shaded). (c) The Scholander plot is used to determine BMR, CIT, Tlc, and insulation (inverse of the slope of the heat requirement). The set point for Tcore is where the heat requirement line intersects the Ta axis. The thermoneutral zone starts at the Tlc. Data (black circles) obtained from one lean subject and analyzed by branch-chain regression (blue lines) are included as an example.