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. Author manuscript; available in PMC: 2019 Sep 9.
Published in final edited form as: Cell Rep. 2019 Aug 27;28(9):2256–2263.e3. doi: 10.1016/j.celrep.2019.07.074

Figure 2. vHPC Inputs Are Stronger onto D1+VTA Cells in Naive Mice.

Figure 2.

(A) Left: schematic for injections of AAV-ChR2-eYFP into the vHPC and CTB-647 into the VP or the VTA. Right: representative image of viral expression in the vHPC (scale bar, 500 μm) and of dense vHPC axon labeling in the NAcMS (scale bar, 100 μm).

(B) Left: vHPC inputs evoke larger EPSCs at D1+VTA MSNs compared with neighboring D1− MSNs. Middle: summary of the absolute amplitude of vHPC-evoked AMPAR EPSCs at D1− and D1+VTA MSNs, where lines indicate pairs of recorded neurons. Right: summary of D1+VTA/D1− amplitude ratios for AMPAR EPSCs at −70 mV and NMDAR EPSCs at +40 mV.

(C) Similar to (B), showing no bias of vHPC inputs onto pairs of D1+VP and D1− MSNs.

(D) Left: schematic for injections of AAV-ChR2-eYFP into the BLA and CTB-647 into the VP or the VTA. Right: representative image of viral expression in the BLA (scale bar, 500 μm) and of BLA axon labeling in the NAcMS (scale bar, 100 μm).

(E) Left: there is no bias of BLA-evoked EPSCs at D1+VTA MSNs compared to neighboring D1− MSNs. Middle: summary of the absolute amplitude of BLA-evoked AMPAR EPSCs at D1− and D1+VTA MSNs, where lines indicate pairs of recorded neurons. Right: summary of D1+VTA/D1− amplitude ratios for AMPAR EPSCs at −70 mV and NMDAR EPSCs at +40 mV.

(F) Similar to (E) showing no bias of BLA-evoked EPSCs at D1+VP MSNs compared to neighboring D1− MSNs.

Average traces are presented as mean ± SEM. Ratio data are presented as geometric mean with 95% CI on logarithmic axes. *p < 0.05.

See also Figure S1.