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. Author manuscript; available in PMC: 2019 Sep 9.
Published in final edited form as: Neurotoxicology. 2018 Apr 21;67:73–83. doi: 10.1016/j.neuro.2018.04.013

Figure 4.

Figure 4

(Experiment 2.). The VEP F2 amplitude (mean ± SE) recorded to 80% contrast stimuli plotted as a function of group mean T4 reduction (% control) for T4 levels measured from littermate pups on PN14 (upper panel) or PN21 (lower panel). Pups treated with 1 ppm PTU showed approximately a 50% (PN14) or a 20% (PN21) reduction of T4. Pups treated with 2 or 3 ppm PTU showed greater than 80% (PN14) or 60% (PN21) reduction of T4. Statistically significant reductions from control were seen in F2 amplitude following 2 or 3 ppm PTU, but not 1 ppm PTU (Figure 3). The results suggested that between a 60% (PN21) and 80% (PN14) reduction of developmental serum T4 was associated with a significant lowering F2 amplitude in adult offspring.