Table 2.
AH Proteins Significantly Altered in Subjects With POAG
|
S. No. |
Protein Name |
Gene Symbol |
UniProt ID |
OR (95% CI) |
P
Value |
Fold Change |
| 1 | Ig κ chain C region | IGKC | A0A087X130 | 1.31 (1.065–1.609) | 0.0104 | 13.56 |
| 2 | Inter-α-Trypsin Inhibitor heavy chain4 | ITIH4 | B7Z544 | 1.64 (1.065–2.521) | 0.0248 | 4.10 |
| 3 | Apolipoprotein C-III | APOC3 | A3KPE2 | 1.90 (1.181–3.048) | 0.0081 | 3.36 |
| 4 | Isocitrate dehydrogenase [NAD] subunit α | IDH3A | H0YLI6 | 1.98 (1.141–3.434) | 0.0152 | 3.11 |
| 5 | cDNA FLJ42083 fis, clone TCERX2000613 | LOC105369216 | Q6ZVM5 | 1.90 (1.033–3.508) | 0.0391 | 2.98 |
| 6 | Serine/cysteine proteinase inhibitor clade F | SERPINF2 | C9JPV4 | 1.55 (1.046–2.304) | 0.0292 | 2.94 |
| 7 | Niemann-Pick disease, type C2 | NPC2 | G3V2V8 | 1.99 (1.150–3.452) | 0.0139 | 2.88 |
| 8 | Succinate-CoA ligase subunit β | SUCLG2 | B4DRV2 | 2.57 (1.147–5.752) | 0.0218 | 2.70 |
| 9 | KIAA0100 | KIAA0100 | K7EQ86 | 2.62 (1.255–5.472) | 0.0103 | 2.29 |
| 10 | CCR4-NOT transcription complex subunit 4 | CNOT4 | B3KQ99 | 3.80 (1.421–10.171) | 0.0078 | 2.23 |
| 11 | Aquaporin 4 | AQP4 | L0R6C7 | 3.63 (1.381–9.563) | 0.0090 | 2.11 |
| 12 | Collagen, type XVIII, α 1 | COL18A1 | Q8NG19 | 2.64 (1.030–6.756) | 0.0432 | 2.08 |
| 13 | NACHT and WD repeat domain containing 1 | NWD1 | F8W0U9 | 2.09 (1.069–4.068) | 0.0312 | 2.07 |
| 14 | Transmembrane protein 120B | TMEM120B | H0YG77 | 1.59 (1.025–2.456) | 0.0383 | 2.06 |
| 15 | Leucine rich repeat containing 34 | LRRC34 | G3V115 | 2.40 (1.143–5.028) | 0.0207 | 1.98 |
| 16 | IgGFc-binding protein | FCGBP | A0A087WUZ2 | 2.10 (1.114–3.966) | 0.0219 | 1.92 |
| 17 | Na+/K+ Transporting ATPase Interacting 2 | NKAIN2 | B3KNZ0 | 2.07 (1.064–4.007) | 0.0321 | 1.92 |
| 18 | Solute Carrier Family 35 Member C2 | SLC35C2 | B7Z6R4 | 2.29 (1.095–4.798) | 0.0278 | 1.89 |
| 19 | Tetraspanin 14 | TSPAN14 | Q8N2P5 | 2.39 (1.107–5.151) | 0.0265 | 1.88 |
| 20 | Family With Sequence Similarity 171, Member B | FAM171B | A0A087WU95 | 2.28 (1.092–4.758) | 0.0282 | 1.87 |
| 21 | Fetuin-B | FETUB | F8WEP7 | 2.22 (1.079–4.575) | 0.0303 | 1.86 |
| 22 | LDL receptor-related protein-5 | LRP5 | E9PHY1 | 2.25 (1.069–4.725) | 0.0327 | 1.83 |
| 23 | Fibrinogen β chain | FGB | D6REL8 | 1.93 (1.041–3.576) | 0.0368 | 1.82 |
| 24 | Hydroxysteroid (17-β) Dehydrogenase 10 | HSD17B10 | Q5H928 | 2.43 (1.070–5.511) | 0.0339 | 1.80 |
| 25 | Phosphatidylinositol glycan, class C | PIGC | A0A024R900 | 2.06 (1.012–4.190) | 0.0464 | 1.78 |
| 26 | Protein cornichon homolog 1 | CNIH1 | G3V5P8 | 2.66 (1.173–6.048) | 0.0192 | 1.75 |
| 27 | Torsin family 3, member A | TOR3A | A0A024R943 | 2.49 (1.142–5.448) | 0.0218 | 1.73 |
| 28 | Mediator complex subunit MED23 | MED23 | B9TX53 | 2.26 (1.113–4.590) | 0.0240 | 1.68 |
| 29 | Succinate dehydrogenase assembly factor 2 | SDHAF2 | M0QY91 | 2.09 (1.089–4.004) | 0.0267 | 1.67 |
| 30 | Protein COMMD3-BMI1 | COMMD3-BMI1 | Q5T8Z1 | 2.05 (1.016–4.149) | 0.0452 | 1.64 |
| 31 | Inositol polyphosphate 1-phosphatase | INPP1 | C9J128 | 2.12 (1.044–4.302) | 0.0376 | 1.59 |
| 32 | cDNA FLJ57526 | N/A | B4DLF2 | 2.00 (1.036–3.839) | 0.0388 | 1.54 |
| 33 | Rheumatoid factor D5 light chain | V-kappa-3 | A0N5G5 | 2.36 (1.030–5.406) | 0.0424 | 1.46 |