Table 3.
Biological Functions and Pathways Significantly Enriched in Proteins Associated With POAG
|
Term |
Count |
P
Value |
| Uniprot keywords | ||
| Signaling pathways proteins | 15 | 4.1 × 10−4 |
| Glycoprotein | 15 | 1.1 × 10−3 |
| Secreted proteins | 10 | 4.2 × 10−4 |
| Disease mutation | 9 | 1.2 × 10−2 |
| Protease inhibitor | 3 | 8.5 × 10−4 |
| Uniprot sequence features | ||
| Glycosylation site: N-linked (N-GlcNAc) | 14 | 1.0 × 10−3 |
| Signal peptide | 13 | 3.6 × 10−4 |
| Disulfide bond | 9 | 1.8 × 10−2 |
| Glycosylation site: O-linked (O-GlcNAc) | 3 | 3.7 × 10−4 |
| Cellular compartments | ||
| Extracellular exosome | 10 | 1.2 × 10−2 |
| Extracellular region | 8 | 3.6 × 10−3 |
| Blood microparticle | 4 | 1.1 × 10−4 |
| Mitochondrial matrix | 4 | 1.9 × 10−3 |
| External side of plasma membrane | 3 | 5.1 × 10−3 |
| Biological processes | ||
| Negative regulation of endopeptidase activity | 3 | 6.6 × 10−4 |
| Platelet degranulation | 3 | 4.1 × 10−4 |
| Cholesterol homeostasis | 3 | 1.0 × 10−4 |
| Molecular and cellular functions | ||
| Small molecule biochemistry | 8 | 9.9 × 10−5 |
| Lipid metabolism | 7 | 9.9 × 10−5 |
| Molecular transport | 7 | 9.9 × 10−5 |
| Cell death and survival | 6 | 7.4 × 10−4 |
| Vitamin and mineral metabolism | 5 | 4.0 × 10−4 |
| Canonical pathways | ||
| FXR/RXR activation | 4 | 2.5 × 10−5 |
| LXR/RXR activation | 3 | 6.0 × 10−4 |
| Acute phase response signaling | 3 | 1.6 × 10−3 |
| Intrinsic prothrombin activation pathway | 2 | 1.5 × 10−3 |
| Coagulation pathway | 2 | 1.0 × 10−3 |