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. 2019 Sep 4;39(36):7218–7226. doi: 10.1523/JNEUROSCI.2574-18.2019

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Copyright © 2019 Passamonti et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 4. — Mean effects (left) and group difference effects (AD/MCI+>Controls, right) between default mode network (DMN) and subcortical (SC) regions using univariate approach. vACC, ventral Anterior cingulate cortex; PCC, posterior cingulate cortex; IPL, intraparietal lobule; FPN, frontoparietal network; Put, putamen; Hipp, hippocampus, AG, angular gyrus; CN-MFG, middle frontal gyrus (cortical network), SFG, superior frontal gyrus; r, right; l, left. Note that the whole pattern of brain connectivity rather than each connection separately was used to study how subject-specific neuroinflammatory levels influence large-scale network connectivity (Fig. 5). AD/MCI+, Alzheimer's Disease/Mild Cognitive Impairment (positive PET amyloid, 11C PiB PET).