Figure 7.

Changes of total levels of BCN and TNR in the auditory cortex and hippocampus along learning stages. A, Total amount of the 55 kDa BCN (left), full-length BCN (middle), and TNR (right) in auditory cortex measured as the sum of both supernatant and pellet fractions. Whereas total TNR showed no significant reduction in the auditory cortex, cleaved BCN showed a significant reduction across all training stages and recovered during LTR. Full-length BCN was also significantly reduced during early avoidance learning and also within the group of LP animals. B, Total amount of the 55 kDa BCN (left), full-length BCN (middle) and TNR (right) in hippocampus showed only generally reduced levels of the 55 kDa BCN fragment independent of learning stage. For details, see Materials and Methods. *Indicates significant one-way ANOVA and post hoc Tukey tests of multiple comparisons between groups (Table 1F,G). Box plots represent median (bar) and interquartile range, and bars represent full range of data. Plus within each bar represents mean value.