Figure 4.

Dynamic variation in suprathreshold temporal coding over varying degrees of mild to moderate MHL in a representative AN fiber. Change over time after furosemide injection in tuning curve threshold and TTR (A), BFs of suprathreshold TFS/ENV coding and tuning curve CF (B), and below-CF amplitude of TFS/ENV coding (C). Vertical lines in B indicate the 10 dB bandwidth of frequency tuning. Limits of the y-axis in C match Figure 3, C and D, for direct comparison of the smaller MHL effects compared with NIHL effects. MHL peaked from 5–10 min after furosemide injection and recovered almost completely within 35 min. Tonotopic coding of TFS and ENV was generally well preserved during mild to moderate MHL.