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. 2019 Aug 16;12(8):e007547. doi: 10.1161/CIRCINTERVENTIONS.118.007547

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© 2019 The Authors.

Circulation: Cardiovascular Interventions is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 4. — Impairment of coronary flow reserve in progressive aortic stenosis (AS): simulated resting and hyperemic mean coronary blood flow as a function of the severity of AS and estimated orifice area. Induced hyperemia is fundamentally important during circulatory assessment in AS because adaptive hyperemia is already established at baseline—several well-cited studies are flawed in this respect. AVA indicates aortic valve area. Adapted from Garcia et al⁶⁵ with permission. Copyright ©2009, The American Physiological Society.