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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Pharmacol Res. 2019 Aug 8;147:104391. doi: 10.1016/j.phrs.2019.104391

Figure 4:

Figure 4:

Schematic diagram showing crosstalk between miRNA-29 and mi-RNA-let-7 in progressive fibrosis: DPP-4 inhibitors by blocking DPP-4 enzyme interactions, inhibit the TGF-β/ Smad pathway. Inhibited TGF- β/Smad pathway, in turn, induces miR-29 that subsequently inhibit Int-β1 and INF-γ. Inhibition of Int-β1 and INF-γ induce FGFR-1 and induce miR-let-7. miR-let-7 inhibits TGF- β R1. Therefore, miR-29 and miR-let-7 comprise anti-EndMT programs. Int-β1, integrin-β1; INF-γ, Interferon-γ; FGFR, fibroblast growth factor receptor.