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Schematic representation of the mechanism of action underlying the TRPM8 channel activation in IPA. AC, adenylyl cyclase; COX, cyclo-oxygenase; EDHF, endothelium-derived hyperpolarizing factor; sGC, soluble guanylyl cyclase; IP, PGI2 receptor; NOS, NO synthase; PGI2, prostacyclin; ROCK II, Rho-associated protein kinase; transient receptor potential canonical channel; TRPM8, transient receptor potential melastatin 8 channel.
