Table 1:
(A) Table showing the clinical characteristics of 498 patients of the TCGA study [Prostate adenocarcinoma (TCGA, Provisional)] extracted from cBioportal. (B) Table showing the associations between the mRNA expression levels of Nodal and clinical characteristics indicating that Nodal expression is significantly upregulated with higher age (>60 years) and Gleason score (9–10) compared to lower age (≤ 60 years) and Gleason score (6–7), respectively.
| Characteristics | No. of patients (N=498) | % | Characteristics (Number of patients) | Mean Nodal mRNA expression | p value |
|---|---|---|---|---|---|
| Age [Range] | 223 | 44.78 | Age [Range] | 2.48 | 0.0376 |
| ≤ 60 [41–60 yrs] | 275 | 55.22 | ≤ 60 [41–60 yrs] | 3.99 | |
| > 60 [61–78 yrs] | > 60 [61–78 yrs] | ||||
| Gleason score | 45 | 9.04 | Gleason score | 2.60 | 0.042 (GS 6–7 vs. GS 9–10) |
| 6 | 247 | 49.59 | 6–7 (292) | 3.62 | |
| 7 | 64 | 12.85 | 8 (64) | 4.66 | |
| 8 | 138 | 27.71 | 9–10 (142) | ||
| 9 | 4 | 0.80 | |||
| 10 | |||||
| T stage [pT] | 177 | 35.54 | T stage [pT] | 3.19 | 0.5167 |
| T1 | 174 | 34.94 | T1–2 (351) | 2.56 | |
| T2 | 53 | 10.64 | T3–4 (55) | ||
| T3 | 2 | 0.40 | |||
| T4 | 1 | 0.20 | |||
| Unknown | 91 | 18.27 | |||
| NA | |||||
| N stage [pN] | 345 | 69.28 | N stage [pN] | 3.06 | 0.3711 |
| N0 | 80 | 16.06 | N0 (345) | 3.89 | |
| N1 | 73 | 14.66 | N1 (80) | ||
| NA | |||||
| M stage [pM] | 456 | 91.57 | M stage [pM] | 3.326 | 0.2296 |
| M0 | 3 | 0.60 | M0 (456) | 9.072 | |
| M1 | 39 | 7.83 | M1 (3) | ||
| NA | |||||
| Survival status | 488 | 97.99 | Survival status | 3.325 | 0.8937 |
| Alive | 10 | 2.01 | Alive (488) | 2.980 | |
| Dead | Dead (10) | ||||
| |
Overall survival | 3.398 | 0.8253 | ||
| Median | 3.238 | ||||
| |
≤ 30.49 mths | ||||
| |
(249)> 30.49 mths (249) | ||||