TABLE 1.

Clinicopathologic and molecular findings of tumors with NTRK3 fusions

	Patient	Location	cm	G	MC	NE	S100	CD34	Sox10	H3	TRK	Molecular	Clinical FU
1	67/F	Thigh	4	IG	14	−	pos	pos	neg	pos	pos	ETV6-NTRK3a	NA
2	21/F	Paraspinal	8	IG	11	−	pos	pos	neg	pos	pos	TFG-NTRK3b	NED 5 mo
3	1/M	Foot	4	HG	13	+	pos	pos	NA	NA	pos	EML4-NTRK3c	NA
4	60/F	Popliteal	8	HG	6	+	pos	pos	neg	pos	neg	TPM4-NTRK3b	NED 36 mo
5	11/M	Mesentery	11	HG	28	+	pos	pos	NA	NA	pos	NTRK3 b/aa	DOD 1 mo
6	6/F	Retroperit	11	HG	10	+	neg	pos	neg	pos	pos	NTRK3 b/a +a	AWD 4 mo
7	49/F	Abdomino-pelvis	25	HG	28	+	neg	pos	neg	pos	pos	NTRK3 b/a +a	NED 11 mo

Abbreviations: cm, size in cm; G, grade; H3, H3K27me3; HG, high grade; IG, intermediate grade; MC, mitotic count/10 HPFs; NE, necrosis.

^aFISH; b/a, break-apart; +, amplification.

^bArcher FusionPlex assay.

^cTargeted RNA sequencing; FU, follow-up; NA, not available; NED, no evidence of disease; AWD, alive with disease; DOD, dead of disease; mo, months.