Table 1:

Summary of drug uptake transporters involved in protein-protein interaction

Transporter	Interaction Partner	Functional Change?*	Expression Change?*
NTCP	NTCP	No	N/A
	SOAT	↓	↓
OATP1B1	OATP1B1	↓	↓
OATP1B3	OATP1B3	No	No
	OATP1B1	N/A	N/A
	NTCP	N/A	N/A
OSTα	OSTβ	Required for function	Required for membrane expression
OCT1	OCT1	No	N/A
OCT2	OCT2	N/A	N/A
	LAPTM4A	N/A	N/A
	CD63	N/A	N/A
OAT1	OAT1	↓	↓
OAT3	OAT3	N/A	N/A
	Caveolin-1	↑ due to gain of protein-cytoskeletal interaction	Redistribution to non-LRD-rich compartments
	β-actin
	Myosin
OCTN2	Caveolin-1	N/A	N/A
	Flotillin	N/A	N/A

^*Functional and expression change means that the potential changes happened to the target transporter by the interactions with the partner transporters. Arrows represent the increase (↑) or decrease (↓) of function or membrane expression.