Table 1:

Effects of epigenetic pharmacotherapies on drug-seeking behaviors.

Drug of abuse	Epigenetic inhibitor	Target(s)	Route of delivery	Behavioral effect	Reference(s)
Cocaine	TSA	HDACs	systemic	↓ SA	[40]
	Phenylbutyrate	HDACs	systemic	↓ SA	[40]
	Garcinol	HATs	systemic	↓ reinstatement of SA	[113]
	RGFP-966	HDAC3	systemic	↑ extinction of SA	[68]
	RGFP-966	HDAC3	systemic	↑ extinction of CPP	[41]
	RG108	DNMTs	intra-NAc	↓ incubation of craving	[44]
	TSA	HDACs	intra-NAcS	↑ SA	[114]
	JQ1	BETs	systemic and intra-NAc	↓ acquisition of CPP	[43]
	SKLB-639	PRMT1	systemic	↓ acquisition of CPP	[55]
	GSK-J4	KDM6B	systemic	↓ reinstatement of CPP	[54]
	methionine	DNA methylation	systemic	↓ acquisition of CPP	[52]
	BIX01294	GLP/G9a	intra-NAc	↑ acquisition of CPP	[20]
	Sirtinol	Sirtuins	intra-NAc	↓ acquisition of CPP	[42]
Nicotine	phenylbutyrate	HDACs	systemic	↓ acquisition of CPP	[115]
	NaB	HDACs	systemic	↓ reinstatement of SA	[116]
Morphine	NaB	HDACs	systemic	↑ extinction of CPP	[117]
	NaB	HDACs	systemic	↑ acquisition of CPP	[118]
Heroin	JQ1	BETs	intra-DS	↓ SA	[37]
	NaB	HDACs	systemic	↑ reinstatement of SA	[119]
Ethanol	NaB and MS-275	HDACs	systemic	↓ SA	[120]
	RG108	DNMTs	intra-mPFC	↓ SA	[48]
	5-Aza-dc	DNMTs	intra-mPFC	↓ SA	[53]

5-Aza-dc, 5-aza-2′-deoxycytidine; BETs, bromodomain and extra terminal domain; CPP, conditioned place preference; DNMTs, DNA methyltransferases; DS, dorsal striatum; GLP, G9a-like protein; HATs, histone acetyltransferases; KDM6B, lysine demethylase 6B; mPFC, medial prefrontal cortex; NaB, sodium butyrate; PRMT1, protein arginine methyltransferase 1; NAc, nucleus accumbens; NAcS, nucleus accumbens shell; SA, self-administration; TSA, Trichostatin A.