Table 1.
Baseline clinical and MRI statistics of subjects used for a) non-linear SVM analysis (T1-Gd data set), and b) linear SVM analysis (cortical grey matter maps). */+/# indicate significant differences between groups (p < 0.05).
Abbreviations: T treated, NT not treated, SD standard deviation, IQR interquartile range, EDSS expanded disability status scale, bs baseline, y1 year1, Total non-linear SVM) or cortical (linear SVM) GM volume - as obtained from the SPM/VBM8 pipeline, PGMVC percentage gray matter volume change, TCDMS time to CDMS (days)
| Non-linear SVM | Linear SVM | |||||||
|---|---|---|---|---|---|---|---|---|
| placebo | IFN-b | placebo | IFN-b | |||||
| conv- | conv+ | conv- | conv+ | conv- | conv+ | conv- | conv+ | |
| N | 22 | 39 | 49 | 50 | 25 | 44 | 49 | 49 |
| Mean age, years (SD) | 30.6 (7.5) | 29.2 (8.0) | 31.4 (8.1) * | 27.9 (6.8) * | 34.1 (6.3) + | 29.0 (6.7) + | 31.1 (7.8) | 29.8 (7.6) |
| m/f (ratio) | 6/16 (1:2.7) | 12/27 (1:2.2) | 21/28 (1:1.3) | 13/37 (1:2.8) | 8/17 (1:2.1) | 12/32 (1:2.7) | 18/31 (1:1.72) | 12/37 (1:3.08) |
| TCDMS, median (IQR) | 1780 (1805-857) # | 249 (627-74) | 1807 (1820-1794) # | 432 (824-111) | 1798 (1808-1497) | 303 (709-138) | 1808 (1822-1791) | 423 (1027-204) |
| EDSS, median (IQR) | 1.0 (2.0-0.0) | 1.5 (2.0-1.0) | 2.0 (2.0-1.0) | 2.0 (2.5-1.0) | 1.5 (2.0–1.0) | 1.5 (2.0–1.0) | 1.5 (2.0–1.0) | 1.5 (2.0–1.0) |
| N relapse, median (IQR) | 0 (0-0) # | 1.0 (1.0-0.75) # | 0 (0-0) + | 1.0 (1.0-0) + | 0 (0-0) * | 1.0 (1.0-0.75) * | 0 (0-0) + | 1.0 (1.0-0) + |
| N T2 lesions at m24, median (IQR) | 0 (1.25-0) | 0.5 (3.0-0) | 0 (0.75-0) | 0 (0.75-0) | 0 (1.25-0) | 0.5 (3.0-0) | 0 (0.75-0) | 0 (0.75-0) |
| N Gd-lesions at m24, median (IQR) | 0 (0-0) | 0 (1.0-0) | 0 (1-0) | 0 (0.0-0) | 0 (0-0) | 0 (1.0-0) | 0 (1-0) | 0 (0-0) |
| Total (cortical^) GM volume [ml], mean (SD) | 554.7 (177.3) | 575.6 (234.2) | 651.0 (217.1) | 587.2 (265.4) | 251.52 (102.37)^ | 284.0 (56.96) ^ | 303.24 (27.88) ^ | 293.64 (12.75) ^ |