Chart 4. Main treatment regimens recommended for the treatment of primary Pseudomonas aeruginosa infection in bronchiectasis patients.

Treatment regimen	Dose	Frequency
Oral antibiotic + inhaled antibiotic
Oral: Ciprofloxacin +	500-750 mga	12/12 h for 14-21 days
Inhaled: Gentamicin or Nebulized tobramycin or Colistimethate**	80 mg 300 mg 1,000,000 IU	12/12 h for 3 months 12/12 h for 3 months 12/12 h for 3 months
Intravenous antibiotic (antipseudomonal beta-lactam + aminoglycoside) + inhaled antibiotic
Intravenous: Ceftazidime or Cefepime or Piperacillin + tazobactam or Meropenem +	2 g 2 g 4.5 g 2 g	8/8 h (14 days) 8/8 h (14 days) 6/6 h or 8/8 h (14 days) 8/8 h (14 days)
Intravenous: Amikacin or Gentamicin or Tobramycin +	20-30 mg/kg/day (max 1.5 g/day) 3-5 mg/kg/day (max 160 mg/day) 10 mg/kg/day (max 660 mg/day)	24/24 h (14 days) 24/24 h (14 days) 24/24 h (14 days)
Inhaled: Gentamicin or Nebulized tobramycin or Colistimethateb	80 mg 300 mg 1,000,000 IU	12/12 h (3 months) 12/12 h (3 months) 12/12 h (3 months)

Max: maximum. ^aThe dose of 750 mg, p.o., 12/12 h is indicated for patients weighing more than 50 kg. ^bIf inhaled antibiotics are not available, consider treating the primary infection with systemic antibiotics alone.