Chart 5. Inhaled antibiotics available in Brazila and recommended for the treatment of chronic bronchial infection with Pseudomonas aeruginosa in bronchiectasis patients.
| Antibiotic and formulation | Dose | Frequency |
|---|---|---|
| Nebulized colistimethate | 1,000,000 IU | 12/12 h continuously |
| Gentamicinb | 80 mg | 12/12 h continuously (or in alternating cycles of 28 days) |
| Dry powder tobramycin | 112 mg | 12/12 h in alternating cycles of 28 days |
| Nebulized tobramycin | 300 mg | 12/12 h in alternating cycles of 28 days |
a
See details in the text regarding access to inhaled antibiotics. bSome centers dilute the intravenous formulation in 0.9% saline for nebulization; considerable caution should be exercised because of the risk of more side effects and bronchospasm.