Fig. 2.

Photomicrographs of rats’ pancreas (stained with H&E X 400), (A) normal control showing normal histological architecture of the pancreas with centrally located β-cells (arrow); (B) diabetic control showing distortion of the islet with marked necrosis (arrow), vacuolation and decrease in number of β-cells; (C) GLB showing marked elevation in the number of β-cells with Karyopyknosis of some cells (arrow); (D) MCFE-250 and (E) MCFE-500 showing moderate increase in the number of the β-cells with necrosis of some cells (arrow); (F) GLB plus MCFE-250 and (G) GLB plus MCFE-500 showing marked increase in the centrally located β-cells (arrow) with mild vacuolization of its cytoplasm.