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. 2019 May 13;27(6):803–816. doi: 10.1016/j.jsps.2019.05.002

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 5 — Representive anti-somatostatin immunohistochemistry in the islets of langerhans in different experimental groups (X400). (A) Normal control showing incomplete ring of somatostatin content of δ-cells in the peripheral area of the islet (arrow). (B) Diabetic control showing marked elevation of somatostatin content of δ-cells occupying the peripheral and central area of the islet of langerhans (arrow). (C and D) GLB and MCFE-250, respectively, showing moderate increase in somatostatin content of δ-cells (arrow) in the central area of the islet. (E, F and G) MCFE-500, GLB plus MCFE-250 and GLB plus MCFE-500, respectively, showing mild decrease in somatostatin content of δ-cells (arrow) of the islet, compared with diabetic control group. (H) The bar chart represents anti-somatostatin immunopositive staining expressed as area %. Values with different superscripts are significantly different (p ≤ 0.05).