Table 2.

Overview of the results (p-value < 10⁻⁵) from the (A–C) cross-sectional EWAS and the (D) longitudinal EWAS (LSADT sample) of hand grip strength

	CpG	Estimate	SE	P-value	Chr	Position (bp)	Gene	Distance to gene (bp)	Gene—CGI feature
(A) Individual level analysis	cg14304073	− 0.0029	0.0006	2.53E−06	14	91,691,190	DGLUCY	0	3′UTR—open sea
	cg16411857	0.0068	0.0015	5.87E−06	16	57,023,191	NLRC5	0	TSS1500—island
	cg14057711	− 0.0083	0.0018	6.71E−06	17	22,203,489	MTRNR2L1	− 179,498	IGR—open sea
	cg13469425	0.0113	0.0025	7.39E−06	4	48,175,353	TEC	0	Body—open sea
	cg03398865	− 0.0058	0.0013	9.20E−06	5	1,879,554	IRX4	0	Body—shore
(B) Intra-pair analysis all	cg01763947	0.0160	0.0032	1.09E−06	15	92,459,894	SLCO3A1	0	Body—shore
	cg11680027	0.0123	0.0026	2.76E−06	6	63,921,394	LGSN	64,462	IGR—open sea
	cg14140691	0.0100	0.0022	4.97E−06	9	141,012,312	CACNA1B	0	Body—shelf
	cg18809570	0.0116	0.0025	5.25E−06	7	155,437,147	RBM33	0	TSS200—island
	cg14187877	0.0253	0.0055	5.75E−06	4	16,679,554	LDB2	0	Body—open sea
(C) Intra-pair analysis top 50% discordant	cg01763947	0.0274	0.0055	1.47E−06	15	92,459,894	SLCO3A1	0	Body—shore
	cg06663068	0.0176	0.0036	2.11E−06	3	9,994,061	PRRT3; PRRT3*	0	1st Exon; 5′UTR—island
	cg15549075	0.0140	0.0029	2.77E−06	2	46,098,874	PRKCE	0	Body—open sea
	cg27653831	0.0318	0.0067	4.26E−06	16	67,700,515	C16orf86;ENKD1; ENKD1*	0	TSS1500; 5′UTR; 1stExon—island
	cg01874084	0.0314	0.0066	4.86E−06	12	56,320,851	WIBG	0	Body—island
	cg05870108	− 0.0466	0.0100	6.80E−06	X	106,749,745	FRMPD3-AS1	6468	IGR—shore
	cg10314909	− 0.0278	0.0060	7.46E−06	1	2,524,890	MMEL1	0	Body—shelf
(D) Longitudinal analysis (LSADT sample)	cg15245520	2.2127	0.4781	5.00E−06	21	47,411,200	COL6A1	0	Body—shelf
	cg04927341	1.4535	0.3190	6.96E−06	1	86,576,497	COL24A1	0	Body
	cg09714181	− 0.6239	0.1371	7.20E−06	5	126,853,350	PRRC1	0	5′UTR;1stExon—island
	cg20569588	− 1.5613	0.3448	7.79E−06	1	55,267,285	TTC22	0	TSS1500;TSS1500—shore
	cg17070108	2.1001	0.4649	8.22E−06	12	8,758,006	AICDA	0	Body—island

SE standard error, Chr chromosome, bp base pairs, CGI CpG island, UTR untranslated region, TSS transcription start site, IGR intergenic region (CpG is assigned to nearest gene)

*CpG holds different gene feature depending on transcript. Annotation is based on Build 37