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. 2019 Sep 3;10:2095. doi: 10.3389/fimmu.2019.02095

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Copyright © 2019 Park, Kwon, Lee, Kwon, Ko, Kim and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of WKYMVm treatment on myofibroblast differentiation in scleroderma. (A) WKYMVm-induced inhibition of myofibroblast differentiation in scleroderma. The BLM-induced scleroderma mice were treated with or without 1 μM Wm for 3 weeks, and the mock-treated (PBS) and the scleroderma (BLM or BLM + Wm) skin specimens were immunostained with antibodies against α-SMA and ILB-4. (B) The skin specimens were stained with antibodies against Vimentin and phospho-SMAD3. Scale bar = 50 μm. The numbers of α-SMA⁺ILB-4⁻ (C), Vimentin⁺ (D), and Vimentin⁺phospho-SMAD3⁺ (E) cells were quantified under a high-power field. Data represent mean ± SD (n = 8 per group). *p < 0.05, **p < 0.01, ***p < 0.001.