TABLE 2.
Action potential characterization for wild-type (WT) and mutant Nav1.9 channels in small DRG neurons.
Input | Current | ||||||
resistance | threshold | Amplitude | Half-width | ||||
Nav1.9 | RMP (mV) | (MΩ) | (pA) | (mV) | (ms) | AHP (mV) | |
WT | n = 39 | −52.2 ± 1.1 | 574 ± 37 | 189 ± 21 | 117 ± 2.3 | 6.84 ± 0.41 | −62.6 ± 0.77 |
N816K | n = 43 | −45.1 ± 1.2∗∗∗ | 571 ± 34 | 105 ± 13∗∗∗ | 111 ± 2.0 | 7.59 ± 0.38 | −60.7 ± 1.0 |
p-value | 2.58e−5 | 0.945 | 7.70e−4 | 0.0650 | 0.183 | 0.135 |
∗∗∗p < 0.001 versus WT channels.