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. 2019 Sep 3;13:394. doi: 10.3389/fncel.2019.00394

FIGURE 2.

FIGURE 2

Protection of mouse primary astrocytes against ischemic injury with exosomes derived from human iCMs and exosomes derived from mouse NSCs. (A) Cell death assessed by lactate dehydrogenase (LDH) release from mouse primary astrocyte cultures after oxygen/glucose deprivation injury (OGD) with/without exosomes derived from human iCMs. (B) Cell death assessed by LDH in mouse primary astrocyte cultures after OGD with/without exosomes derived from mouse NSCs. (C) Examples of astrocyte cultures stained to assess cell death with propidium iodide (PI, red) after OGD and treated with varying concentrations of exosomes derived from mouse neuronal stem cells. Cells are counterstained with Hoechst (blue) which stains all nuclei. Data are expressed as mean ± SD, all graphs represent pooled data from three individual experiments (n = 4–6 per treatment group for each individual experiment). ∗p < 0.05, ∗∗∗p < 0.0005, compared with the control group. #p < 0.05 versus same dose exosomes derived from human iCMs. WC = wash control.