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. 2019 Sep 3;13:395. doi: 10.3389/fncel.2019.00395

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Copyright © 2019 Shou, Cheung, Gao, Shi and Shaw.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The protective effect of berberine toward AAPH-damaged C17.2 neural stem cells. (A) AAPH induced C17.2 cell death. (B) Berberine protected C17.2 cell from AAPH (7.38 mM) induced oxidative damage. 1.25, 12.5, and 100 μM of vitamin C was used as the positive control. (C) Cell morphology after AAPH (7.38 mM) and berberine (1.69 μM) treatment. The data represent the mean ± SEM. ## and ### indicated to compare with AAPH only. ^∗P < 0.05, ^∗∗ or ## P < 0.01 and ^∗∗∗ or ###P < 0.001. NS, no significance.