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. 2019 Sep 3;13:395. doi: 10.3389/fncel.2019.00395

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Copyright © 2019 Shou, Cheung, Gao, Shi and Shaw.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Antiapoptotic pathway of berberine. (A–C) Cell apoptosis detected by flow cytometry, (A) AAPH (7.38 mM) treated cells; (B) AAPH (7.38 mM) and berberine (1.69 μM) treated cells. (C) Apoptotic cells percentage (Q2 + Q4, calculated from three independent experiments). (D) mRNA levels of anti-apoptotic gene (Bcl-2) and apoptotic genes (Bax and Caspase 3) in Step one. (E) Western blot analysis of Bcl-2 and Bax in Step one. (F,G) Quantification of protein blots. (H) Western blot analysis of Caspase 3 and cleaved Caspase 3 in Step one. (I) Quantification of protein blots. The data represent the mean ± SEM. ^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001.