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. 2019 Sep 3;10:951. doi: 10.3389/fphar.2019.00951

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Copyright © 2019 Yang, Zang, Shan, Guo, Wu, Wang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scheme 1 — Synthetic routes of the apocynin derivatives D5 and D6. a) benzyl bromide, K₂CO₃, Dimethylformamide, 40°C, 4 h; b) Br₂, CHCl₃, r.t., 2 h; c) aniline, C H₃CN, NaHCO₃, r.t., 12 h; d) para-fluoroaniline, CH₃CN, NaHCO₃, r.t., 12 h.