Table 2.
Apparent permeability coefficients (Papp) of the compounds in BBB cell model.
| Compound | Standard curve | C0 (μM) | Papp × 10−6 (cm/s) |
|---|---|---|---|
| D1 | y = 85.9121x + 6.9052 | 20 | 4.95 ± 0.39 |
| D5 | y = 47.5216x + 2.4375 | 100 | 10.34 ± 0.31 |
| D6 | y = 37.0426x + 3.9065 | 100 | 8.68 ± 0.45 |
| D13 | y = 121.2051x −1.4975 | 20 | 5.41 ± 0.52 |
| D14 | y = 224.1600x + 10.6510 | 20 | 4.24 ± 1.30 |
| D16 | y = 110.5854x + 2.5641 | 20 | 2.54 ± 0.58 |
| D21 | y = 124.1046x + 5.4653 | 100 | 6.08 ± 0.65 |
| D22 | y = 109.6889x + 2.8041 | 100 | 5.42 ± 0.58 |
| D31 | y = 107.0040x + 9.0208 | 20 | 11.97 ± 0.94 |
| D33 | y = 111.0032x + 2.7632 | 20 | 9.58 ± 2.35 |
| D34 | y = 173.8767x −14.2328 | 20 | 11.89 ± 1.53 |
| TMZ | y = 134.6431x + 3.4643 | 20 | 7.74 ± 0.34 |
C 0: the initial concentrations of compounds. Papp: Transport of the compounds from the apical to basolateral side at 90 min. Values were the means ± SD (n = 3-4).
TMZ, temozolomide.